Stage 3 Mesothelioma

Stage 3 mesothelioma is an advanced stage of this cancer. Tumors have spread from the lining of the lungs (pleura) to more parts of the body, like the diaphragm, heart, and lymph nodes. The average stage 3 mesothelioma life expectancy is around 19 months, but patients could live longer with treatments like surgery, chemotherapy, and radiation.

Free Case Review

What Is Stage 3 Mesothelioma?

Stage 3 mesothelioma has spread beyond the pleura and into organs throughout the chest. Many patients develop noticeable symptoms like chest pain or a cough and are diagnosed in this stage.

Since it’s an advanced stage of mesothelioma, the prognosis (health outlook) is less favorable than earlier stages. However, some patients can live for over a decade if their cancer responds well to different treatment options.

Quick Facts on Mesothelioma Stage 3
  • Average life expectancy: Nearly 19 months with surgery
  • Causes: Only known cause of mesothelioma at any stage is asbestos exposure
  • Spread: Regional spread from pleura to tissues, organs, and nearby lymph nodes, but distant spread hasn’t occurred
  • Symptoms: Chest pain, shortness of breath, fluid buildup, fatigue, and more
  • Treatments: Chemotherapy, immunotherapy, radiation therapy, and sometimes surgery

We can help stage 3 mesothelioma patients find the best doctors and treatments for their case. Connect with a mesothelioma nurse now to see how we can assist you or a loved one.

Speak With a Mesothelioma Nurse
  • Find Top Doctors and Treatments
  • Connect You With Clinical Trials
  • Answer Medical Questions
Talk with Amy

Amy Fair
20+ Years Helping
Mesothelioma Patients

Substages of Mesothelioma Stage 3

Stage 3 mesothelioma can be classified into 2 substages depending on where and how far the cancer has spread.

The substages of mesothelioma stage 3 are:

  • Stage 3A: The cancer is in the chest wall, diaphragm, pericardium (lining of the heart), or deeper lung tissue. However, it’s still localized to one side of the body and can be treated with surgery.
  • Stage 3B: Mesothelioma cancer cells have grown throughout the chest space and can’t be removed with surgery. Tumors may reach muscles or tissue around the ribs, peritoneum (abdominal lining), and pericardium on both sides of the chest.

“With mesothelioma, they save stage 4 for if it spreads to different organs. So, even though my husband is being torn up by this, it’s only considered stage 3B.”

— Connie Bonnin, wife of mesothelioma patient Alan Bonnin

Stage 3 Mesothelioma Symptoms

By stage 3, symptoms of mesothelioma may start to become more noticeable or disruptive.

Mesothelioma stage 3 symptoms include:

  • Coughing up blood
  • Fatigue
  • Fever
  • Fluid buildup in the lining of the lungs (pleural effusion)
  • Pain that radiates from the chest to the back
  • Persistent cough
  • Shortness of breath
  • Unexplained weight loss

“By this stage of mesothelioma, symptoms are typically noticeable and interfere with everyday life. Chest pain and pressure may worsen, and breathing may become increasingly labored.”

— Moffitt Cancer Center

If you notice any of these symptoms, talk with your doctor immediately to begin diagnostic testing.

Diagnosing Stage 3 Mesothelioma Cancer

Getting an accurate and prompt mesothelioma diagnosis allows patients to access treatments that can ease symptoms and hopefully allow them to live longer.

To diagnose mesothelioma stage 3, doctors use tests like:

  1. A physical exam to discuss medical history and symptoms. Patients should mention any history of asbestos exposure during this appointment.
  2. Blood tests to rule out other conditions and look for signs of cancer.
  3. Imaging tests like chest X-rays, CT scans, MRIs, and PET scans to identify any abnormal tissue or fluid buildup.
  4. A biopsy to take a fluid or tissue sample to determine if cancer is present. This is the only way to know for sure if you have mesothelioma.

After confirming your mesothelioma diagnosis, doctors will then use the results of your imaging scans to determine if your cancer is in stage 3. This will also inform which treatments can be used in your case.

Contact one of our on-staff nurses now to get help finding a trusted mesothelioma specialist who can accurately diagnose you.

Speak With a Mesothelioma Nurse
  • Find Top Doctors and Treatments
  • Connect You With Clinical Trials
  • Answer Medical Questions
Talk with Amy

Amy Fair
20+ Years Helping
Mesothelioma Patients

Stage 3 Mesothelioma Prognosis

A mesothelioma prognosis helps patients understand what to expect after their diagnosis. Generally speaking, the prognosis for mesothelioma stage 3 is less favorable than earlier stages. Patients typically live for less than 2 years in stage 3.

However, prognosis depends on several factors and is unique for every patient.

These factors include:

  • Age: Younger patients can often endure more aggressive treatments than older patients, potentially allowing them to live longer with mesothelioma stage 3.
  • Health and lifestyle: Patients with good overall health and no other chronic conditions may have more treatment options available.
  • Mesothelioma cell type: Mesothelioma tumors consist of different cell types. Tumors with mainly epithelioid cells (the most common type) respond better to treatment.

Mesothelioma prognosis is measured using life expectancy and survival rate. Learn about each below.

Stage 3 Mesothelioma Life Expectancy

Doctor with patientLife expectancy refers to how long doctors expect a patient to live after their diagnosis.

A 2023 review of the National Cancer Database (NCDB) found the average life expectancy for stage 3 mesothelioma is nearly 19 months with surgery.

Remember that life expectancy is only an estimate and some patients have lived for longer depending on their treatment plan.

Stage 3 Mesothelioma Cancer Survival Rate

Stage 3 mesothelioma survival rates measure the percentage of patients still alive after a set amount of time (typically 5 years).

The 5-year survival rate for stage 3 mesothelioma is 13%, according to data from the NCDB.

With that said, other stage 3 mesothelioma patients have surpassed the 5-year survival rate in some cases, living a decade or more.

Can Stage 3 Mesothelioma Go Into Remission?

Yes, although it is rare, some patients can achieve remission even during the later stages of mesothelioma.

Remission isn’t a cure. Instead, signs of cancer have disappeared or lessened, potentially giving patients more time to live.

Treatments like surgery, chemotherapy, and more can help you potentially achieve remission and become a long-term survivor.

Contact our nurses now to see how we can help you find the best treatment for you.

Stage 3 Mesothelioma by Type

Pleural mesothelioma, which affects the lungs, is the one type of mesothelioma officially staged with the Tumor-Node-Metastasis (TNM) staging system. The other types of mesothelioma are informally staged.

Learn about the different types of stage 3 mesothelioma below.

Stage 3 Pleural Mesothelioma

Under stage 3 of the TNM system, pleural mesothelioma tumors have spread past the lung lining and into the lungs, chest wall, and pericardium (lining of the heart). However, distant metastasis to other parts of the body has not occurred.

Over 62% of pleural mesothelioma patients are diagnosed in stage 3 according to a Thoracic Cancer report. It marks the point at which many patients start to experience noticeable symptoms, which include a cough, difficulty breathing, and chest pain.

Surgery — a crucial treatment for early-stage pleural mesothelioma patients — may or may not be available depending on cancer spread.

Stage 3 Peritoneal Mesothelioma

Peritoneal mesothelioma, which forms in the abdominal lining, is unofficially staged as “localized” or “advanced” cancer in most cases.

However, doctors sometimes stage peritoneal mesothelioma with the peritoneal cancer index (PCI) staging system.

Using the PCI, doctors divide the abdominal cavity into different sections and assign a score to each based on cancer spread. Stage 3 peritoneal mesothelioma has a PCI score ranging from 21-30.

Stage 3 Mesothelioma Treatment

Doctors can use a wide variety of treatments, including chemotherapy, radiation, immunotherapy, and sometimes surgery, to help patients with stage 3 mesothelioma live longer.

Learn about some of the top stage 3 mesothelioma treatments below.

Mesothelioma Surgery

If a patient has stage 3A mesothelioma, doctors may recommend using surgery (resection) to remove all visible cancer tumors from the body.

Common stage 3 mesothelioma surgeries include:

  • Extrapleural pneumonectomy (EPP): An EPP involves the resection (removal) of the entire lung affected by mesothelioma, the pleura, diaphragm, and pericardium.
  • Pleurectomy/decortication (P/D): A P/D removes the pleura and any visible tumors on the lung surface. This procedure aims to ease symptoms and improve lung function. It is less extensive than an EPP, so recovery times are faster.

Surgery is often combined with other stage 3 mesothelioma treatments like chemotherapy for best results.

“I think patients who have disease that can be resected can have long-term survivals after removal of that disease in conjunction with chemotherapy.”

— Dr. Taylor Ripley, mesothelioma specialist

Surgery isn’t possible for cases of stage 3B mesothelioma. However, doctors can recommend other treatments to help these patients.

Chemotherapy

Chemotherapy drugs can help combat cancer cells throughout the body. For stage 3 mesothelioma, chemotherapy can reduce the size of tumors and slow the spread of cancer cells.

It’s often used as a supplement to surgery. It might be the main treatment if a stage 3 mesothelioma patient can’t safely undergo a surgical procedure.

Radiation

Radiation therapy uses high-energy X-rays to target and shrink tumors. In stage 3, it can help relieve pain and discomfort associated with mesothelioma and may be used with other treatments to improve survival.

Immunotherapy

Immunotherapy boosts the body’s immune system so it can better target and attack cancer cells.

Over the last few years, immunotherapy has proven to be successful in treating mesothelioma, even for those who are not good candidates for surgery in stage 3.

Clinical Trials

Clinical trials test novel therapies and approaches to improve mesothelioma treatment and offer hope for patients with stage 3 mesothelioma.

While not all patients may be eligible, these approaches can provide access to cutting-edge treatments that may have the potential to improve survival rates and enhance quality of life.

Stage 3 Mesothelioma Survivors

While stage 3 is considered advanced and harder to treat, many mesothelioma patients have lived longer than expected. Some have even become long-term survivors.

Notable stage 3 mesothelioma survivors include:

  • Alan Bonnin: Alan was exposed to asbestos throughout his life, leading to his mesothelioma diagnosis in 2022. Alan bravely fought the cancer for three years and filed a mesothelioma lawsuit to afford treatments and financially protect his family.
  • John Panza: Diagnosed in 2012 at just 38 years old, John received aggressive surgery, chemotherapy, and radiation to improve his life expectancy as much as possible. John is still alive today and is approaching 15 years of survivorship.
  • Sid Toney: Following his stage 3 mesothelioma diagnosis, Sid decided on an aggressive treatment plan to spend as much time with his wife, children, and grandchildren as possible. Sid became a 6-year survivor.

“I just go through it. It is the challenge that I’ve been presented, and I guess that’s what I have to work with.”

— John Panza, stage 3 mesothelioma survivor

Connecting with experienced mesothelioma doctors after a diagnosis is the best way to work toward survivorship. Cancer specialists can recommend treatments to help you live as long as possible.

Get Help for a Mesothelioma Stage 3 Diagnosis

If you or a loved one has been diagnosed with stage 3 mesothelioma, you’re not alone. Many others develop mesothelioma each year, and most patients are diagnosed in stage 3.

While a diagnosis can be scary and shocking, our mesothelioma nurses can help you access the resources you need.

Work with our team to:

  • Connect with top mesothelioma doctors
  • Find the best treatments for your case
  • Get supportive resources to make life with cancer easier
  • Pursue financial compensation and justice

Lung Cancer Group is ready to assist you and your family in any way we can following a stage 3 mesothelioma diagnosis.

Connect with one of our nurses now or call (877) 446-5767 to get started.

Mesothelioma Stage 3 FAQs

Can you survive stage 3 mesothelioma?

Yes, it may be possible for you or a loved one to survive stage 3 mesothelioma. The best way to work toward long-term survivorship is to pursue treatments that can remove, shrink, or destroy cancer tumors.

“I would not wish this disease on anyone,” said Sid Toney, who survived stage 3 mesothelioma for 6 years thanks to surgery and other treatments. “But I know I have shown my family how to face this thing head on.”

Contact our team now for help finding the best treatments that could help you survive stage 3 mesothelioma.

The life expectancy for mesothelioma stage 3 is nearly 19 months, according to data from the NCDB.

Some patients have been able to live for even longer thanks to treatment. John Panza is still alive nearly 15 years after his stage 3 mesothelioma diagnosis in 2012 thanks to aggressive treatments.

On imaging scans, stage 3 mesothelioma looks like sheet-like growths or nodules around the lung. Doctors will also see signs of cancer in other areas beyond the lungs, including in the heart lining, diaphragm, and the lung itself.

Oncologists (cancer doctors) will use imaging scans to look for possible signs of mesothelioma and remove a biopsy sample to confirm that you have cancer.

They can then refer back to the imaging tests to see how far the cancer has spread and determine your stage.

There is currently no known cure for any stage of mesothelioma. However, treatments can potentially help improve survival and ease symptoms.

Common stage 3 treatments include chemotherapy, radiation therapy, immunotherapy, and in some cases, surgery. Some stage 3 mesothelioma patients have lived longer than expected thanks to these treatments.

Stage 3B is a substage of stage 3 mesothelioma. Here, the cancer has spread throughout the chest, reaching the abdomen and both lungs.

Since it is more widespread, stage 3B mesothelioma patients may not be good candidates for surgery. However, other therapies can potentially allow patients to live longer.

Call (877) 446-5767 now to connect with one of our mesothelioma nurses who can help you find top treatments.

Lung Cancer Group was established by a team of caring advocates so those with lung cancer and other asbestos-related diseases can get the help they deserve. Our site provides the most accurate and up-to-date information about lung cancer, its link to asbestos, and financial compensation available to patients. Contact us to learn more and get assistance.

  1. American Cancer Society. (n.d.). Malignant Mesothelioma Stages. Retrieved from https://www.cancer.org/cancer/types/malignant-mesothelioma/detection-diagnosis-staging/staging.html. Accessed on May 20, 2025.
  2. American Cancer Society. (2023, March 2). Survival Rates for Malignant Mesothelioma. Retrieved from https://www.cancer.org/cancer/types/malignant-mesothelioma/detection-diagnosis-staging/survival-statistics.html. Accessed on May 20, 2025.
  3. Banks, K. C., Ossowski, S., Hung, Y., et al. (December 2022). Comparison of Survival by Multimodal Treatment Regimen Among Malignant Pleural Mesothelioma Patients in an Integrated Health System. Clinical Lung Cancer. Retrieved from https://www.sciencedirect.com/science/article/pii/S1525730422002029. Accessed on May 20, 2025.
  4. Bou-Samra, P., Chang, A., Azari, F., et al. (2023, April 16). Epidemiological, therapeutic, and survival trends in malignant pleural mesothelioma: A review of the National Cancer Database. Cancer Medicine. Retrieved from https://onlinelibrary.wiley.com/doi/10.1002/cam4.5915. Accessed on May 20, 2025.
  5. Cleveland Clinic. (2025, April 18). Mesothelioma. Retrieved from https://my.clevelandclinic.org/health/diseases/22432-mesothelioma. Accessed on May 20, 2025.
  6. Mayo Clinic. (2024, December 5). Mesothelioma. Retrieved from https://www.mayoclinic.org/diseases-conditions/mesothelioma/symptoms-causes/syc-20375022. Accessed on May 20, 2025.
  7. Mesothelioma Applied Research Foundation. (n.d.). Mesothelioma patients who had the EPP (extrapleural pneumonectomy) discuss their experience. Retrieved from https://www.youtube.com/watch?v=tKfENMo2Z4k. Accessed on May 20, 2025.
  8. Moffitt Cancer Center. (n.d.). Mesothelioma Stages. Retrieved from https://www.moffitt.org/cancers/mesothelioma/diagnosis/stages/. Accessed on May 20, 2025.
  9. National Cancer Institute (NCI). (2024, July 19). Malignant Mesothelioma Treatment PDQ. Retrieved from https://www.cancer.gov/types/mesothelioma/patient/mesothelioma-treatment-pdq. Accessed on May 20, 2025.
  10. Rojas, L., et al. (n.d.). Characteristics and long‐term outcomes of advanced pleural mesothelioma in Latin America (MeSO‐CLICaP). Retrieved from https://pmc.ncbi.nlm.nih.gov/articles/PMC6397921/. Accessed on May 20, 2025.
Free Case Review

Get Financial Compensation for Lung Cancer

  • Afford medical expenses and any other bills
  • Find peace of mind for you and your family
  • Get justice from the companies that harmed you

Call (877) 446-5767 or fill out the form to connect with our team and pursue financial compensation after a lung cancer diagnosis.

Start a Free Case Review
I understand by submitting this form that I am providing my consent to be contacted by Sokolove Law and its co-counsel, potentially using automated technology, at the number provided regarding my potential claim/their services. Consent is not required to use their services. Msg frequency varies, and message and data rates may apply. Reply HELP for help or STOP to unsubscribe. SMS Terms of Service. I understand and agree that by submitting this form I agree to the Privacy Policy and Terms of Use and that this form does not create an attorney-client relationship and is not confidential or privileged and may be shared.

Secure Submission

Call us at (877) 446-5767 Talk to us via Live Chat